张肖楠。特聘研究员，博士生导师。2014年于华东理工大学获得博士学位。2015至2022年在美国南加州大学药学院先后从事博士后与助理研究员的工作。至今以第一或共同第一作者在Nature Communications、Science Advances、Journal of Controlled release、Angewandte Chemie International Edition 、ACS Catalysis、Chemical Science 等国际主流学术期刊上发表研究论文十余篇。主要研究方向包括蛋白质翻译后修饰及其在疾病治疗中的应用、基于抗体的药物研发、蛋白质靶向降解策略的设计和应用等。
代表性研究论文：
1. Xiao-Nan Zhang (co-first author), Albert T. Lam, Qinqin Cheng, Valentine V. Courouble, Timothy S. Strutzenberg, Jiawei Li, Yiling Wang, Hua Pei, Bangyan L. Stiles, Stan G. Louie, Patrick R. Griffin, and Yong Zhang*. Discovery of an NAD+ analogue with enhanced specificity for PARP1. Chem. Sci. 2022,13, 1982-1991.
2. Zhefu Dai, Xiao-Nan Zhang (co-first author), Qinqin Cheng, Fan Fei, Tianling Hou, Jiawei Li, Alireza Abdolvahabi, Junji Watanabe, Hua Pei, Goar Smbatyan, Jianming Xie, Heinz-Josef Lenz, Stan G. Louie4 and Yong Zhang*. Site-Specific Antibody-Drug Conjugates with Variable Drug-to-Antibody-Ratios for AML therapy. J. Control. Release. 2021,336, 433-442.
3. Zhefu Dai, Xiao-Nan Zhang (co-first author), Fariborz Nasertorabi, Qinqin Cheng, Jiawei Li, Benjamin B. Katz, Goar Smbatyan, Hua Pei, Stan G. Louie, Heinz-Josef Lenz, Raymond C. Stevens, and Yong Zhang*. Synthesis of Site-Specific Antibody-Drug Conjugates by ADP-Ribosyl Cyclases. Sci. Adv. 2020, 6, eaba6752.
4. Xiaojing Shi, Xiao-Nan Zhang (co-first author), Jingwen Chen, Qinqin Cheng, Hua Pei, Stan G. Louie, Yong Zhang*. A Poly-ADP-Ribose Polymer-Based Antibody-Drug Conjugate. Chem. Sci. 2020, 11, 9303-9308.
5. Xiao-Nan Zhang (co-first author), Qinqin Cheng, Jingwen Chen, Albert T. Lam, Yanran Lu, Zhefu Dai, Hua Pei, Nikolai M. Evdokimov, Stan G. Louie, Yong Zhang*. A Ribose-Functionalized NAD+ with Unexpected High Activity and Selectivity for Protein Poly-ADP-Ribosylation. Nat. Commun. 2019, 10, 4196.
6. Zhefu Dai, Xiao-Nan Zhang (co-first author), Fariborz Nasertorabi, Qinqin Cheng, Hua Pei, Stan G. Louie, Raymond C. Stevens, Yong Zhang*. Facile Chemoenzymatic Synthesis of a Novel Stable Mimic of NAD+. Chem. Sci. 2018, 9, 8337-8342. (Featured in Front Cover)
7. Xiao-Nan Zhang, Gen-Qiang Chen, Xiang-Ying Tang, Yin Wei, Min Shi*. Tertiary Phosphines-Catalyzed Annulations of Maleimides or Maleic Anhydride with 4,4-Dicyano-2-methylenebut-3-enoates. Angew. Chem. Int. Ed. 2014, 53, 10768-10773.
8. Xiao-Nan Zhang, Min Shi*. Phosphine-Catalyzed [3+2] Cycloaddition of 4,4-Dicyano-2-methylenebut-3-enoates with Benzyl Buta-2,3-dienoate and Penta-3,4-dien-2-one. ACS Catal. 2013, 3, 507-512.
