博士生导师 刘志达

发布时间：2025-09-28浏览次数：10

Email：zhidaliu@cpu.edu.cn


刘志达，教授，博士生导师，中国药科大学生物药物学院。2015年于中国科学院生物物理研究所获得博士学位，2015-2020年先后在芝加哥大学和美国德克萨斯州西南医学中心从事博士后研究工作。2021年加入山西高等创新研究院。2025年入职中国药科大学，入选兴药领军学者。主要研究方向为肿瘤及感染免疫治疗药物（融合蛋白、环状RNA及工程化免疫细胞）的研发及其作用机制研究、新型环状RNA制备系统的开发及其在疫苗、蛋白替代疗法和体内工程化免疫细胞疗法中的应用。研究成果已发表SCI论文40余篇，主要研究成果以第一，共同第一作者或共同通讯作者身份发表在Science Immunology, Cancer Cell, Nature Immunology, Nature Communications, Cell, Cell Reports Medicine, Science Advances，ACS Nano，Exploration，Theranostics, Oncoimmunology，Cellular and Molecular Immunology以及Cell Discovery等领域权威杂志上。

代表性论文：

  1. Liu Z, Han C, Dong C, Shen A, Hsu E, Ren Z, Lu C, Liu L, Zhang A, Timmerman C, Pu Y, Wang Y, Chen M, Qiao J, Fu Y-X*. Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity. Science Immunology. 2019 Aug 9; 4(38). pii: eaav6473. (IF 17.6)

  2. Qiao J, Liu Z (Co-first author), Dong C, …, Fu K, Peng J, Wang Y, Ren Z, Han C, Xu T, Fu Y-X*. Targeting tumors with IL-10 prevents dendritic cell-mediated CD8+ T cell apoptosis. Cancer Cell. 2019 Jun 10;35(6):901- 915.e4. (IF 48.8)

  3. Han C, Liu Z (Co-first author), Zhang Y, Shen A, Dong C, et.al., Jian Q, Fu Y-X*. Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling. Nat Immunol. 2020. 21, pages 546–554. (IF 27.7)

  4. Liu Z, Zhou C, Qin Y, Wang Z, Wang L, Wei X, Zhou Y, Li Q, Zhou H, Wang W, FuY-X*,ZhuM*,LiangW*.Coordinatingantigencytosolicdeliveryanddangersignaling toprogrampotentcross-priming by micelle-based nanovaccine. Cell Discov. 2017 Apr 4;3:17007. (IF 13)

  5. LiuZ& Fu Y-X*. Chemotherapy Induces Cancer-Fighting B Cells. Cell.2020.(IF 66.85, Invited preview)

  6. Liu Z, Han C & Fu Y-X*. Targeting innate sensing in the tumor microenvironment to improve immunotherapy. Cell Mol Immunol. 2019 Nov doi:10.1038/s41423-019- 0341-y (IF21.8, Invited review)

  7. Wang L, Dong C,…, Xie J, Yu G*, Wang L*, Chen X*, Liu Z* (Correspondingauthor). Developing an enhanced chimeric permuted intron-exon system for circular RNA therapeutics. Theranostics. 2024; 14(15):5869-5882. (IF 12.4)

  8. Wu J,…Gao GF*, Liu Z* (Correspondingauthor). Circular RNA vaccine encoding a chimeric immunogen of B6 and M1 demonstrates robust immune responses against Monkeypox virus. Cell Reports. 2025. (Accepted）

  9. Yang K, …Liu Z* (Co-correspondingauthor), Yu G*. Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy. Science Advances, 2025.(IF 11.7)

  10. Li Y, …Ma L,* Mao Z*, Liu Z* (Co-correspondingauthor), Yu G*. Catalytic Hybrid Lipid Nanoparticles Potentiate Circle RNA-Based Cytokine Immunotherapy. ACAS Nano, 2025. (IF 15.8)

  11. Li H, LiuZ*(Co-correspondingauthor),…, Brekken R. A.*, AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells. Cell Reports Medicine, 2022, 3(3). (IF 11.7)

  12. Li X, Liu Z (Co-first author), …, Boothman D-A, QiaoJ,WangY,HuangX,FuY-X*.NQO1targetingprodrugtriggersinnatesensingto overcome checkpoint blockade resistance. Nat Commun. 2019 Jul19; 10(1):3251. (IF 14.7)

  13. Feng Q, LiuZ(Co-firstauthor),Yu X, Huang T, et. al., Sumer B, Li B, Fu Y-X*, Gao J*. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13(1):4981. (IF 14.7)

  14. Wang L, Wang L, Dong C, Liu J, G S*, Liu Z* (Correspondingauthor).Exploring the potential and advancements of circular RNA therapeutics. Exploration. 2025 May1;5(4):e20240044.


代表性专利：

  1. 刘志达,高福,王连庆,王磊,董春波.一种体外进行RNA环化的方法 (专利号：ZL 202410221887.0)

  2. 刘志达,高福,王连庆,王磊,董春波. 一种基于I型内含子核酶体外制备环状RNA的系统及其应用 (专利号：ZL202410221889.X)

  3. 刘志达,王磊,王连庆,史晋朝,董春波,张卫兵.一种利用嵌合 PIE 系统体外制备环状 RNA 的方法与应用(专利号：ZL202410088465.0)

  4. 刘志达,高福,王磊, 王连庆,董春波.一种环状核酶系统及其应用（专利号：ZL 202410701586.8）

  5. 刘志达,韩鹏程,董春波,乔永峰,赵欣,李维新,胡洪,张卫兵.一种基于CD24和ACE2的双功能融合蛋白(专利号：ZL202310743511.1)