李家璜，副教授，硕士生导师。2004年南京工业大学获得博士学位,同年进入南京大学进行博士后研究。2009年-2020年南京大学任教，于2020年入职中国药科大学生物药物学院。主持国家自然科学基金面上项目1项、江苏省自然科学基金1项，作为分课题负责人承担国家高技术研究发展计划课题1项、参与国家自然科学基金面上项目1项、参与江苏省科技成果转化资金项目1项；获国家发明专利授权1项，申请国家发明专利1项；作为编委编写教材2部；作为主要完成人获得2018年教育部技术发明奖一等奖、2018年中国发明协会发明创业成果奖一等奖。
研究方向：
（1）基于结构生物信息学进行蛋白质/多肽结构与功能分析和改造
（2）酶理性设计研究
（3）肿瘤靶向性细菌介导的肿瘤组织靶向性递送和基因治疗及其机制研究
近年发表论文:
1. Kemin Lv, Wenyu Shao, Marcelo Monteiro Pedroso, Jiayu Peng, Bin Wu*, Jiahuang Li*(通讯), Bingfang He, Gerhard Schenk. Enhancing the catalytic activity of a GH5 processive endoglucanase fromBacillus subtilis BS-5 by site-directed mutagenesis. International Journal of Biological Macromolecules 2021,168: 442-452.
2. Cheng-Jie LIANG(共一), Jia-Huang LI(共一), Zhen ZHANG，Ju-Yan ZHANG，Shu-Qun LIU*, Jie YANG*. Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer’s disease. Acta Pharmacologica Sinica. 2018, 39:1421–1438.
3. Jiahuang Li, Junfei Sun, Bin Wu *, Bingfang He. Combined utilization of nutrients and sugar derived from wheat bran for D-Lactate fermentation by Sporolactobacillus inulinus YBS1-5. Bioresource Technology 2017, 229: 33–38 .
4. Hong-jin Tang, Lin Yang, Jia-huang Li*(通讯), Jun Chen*(通讯). Molecular modelling studies of 3,5-dipyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors using 3D-QSAR, Topomer CoMFA, molecular docking and molecular dynamic simulations. Journal of the Taiwan Institute of Chemical Engineers. 2016, 68: 64-73.
5. Zhu F, Zhuang Y, Wu B, Li J*(通讯), He B*(通讯). Rational Substitution of Surface Acidic Residues for Enhancing the Thermostability of Thermolysin. Appl Biochem Biotechnol. 2016, 178(4): 725-38.
6. Jiahuang Li, Yuan Chen, Jie Yang*, Zichun Hua*. Thermal and Urea Induced Unfolding Processes of Glutathione S-Transferase by Molecular Dynamics Simulation. Biopolymers.2015, 103(5): 247-259.
7. Xiufeng Liu, Kai Wang, Ningjun Duan, Yan Lan, Pengcheng Ma, Heng Zheng, Weijuan Zheng*(通讯), Jiahuang Li*(通讯) and Zi-chun Hua*(通讯). Computational prediction and experimental validation of low-affinity target of triptolide and its analogues. RSC Adv. 2015, 5: 34572-34579.
8. Jingwei Huang, Weijian Hua, Jiahuang Li*(通讯), Zichun Hua*(通讯). Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase. Molecular Medicine Reports. 2015, 12: 5787-5795
9. Chen G, Tang B, Yang BY, Chen JX, Zhou JH, Li JH*(通讯), Hua ZC*(通讯). Tumor-targeting Salmonella typhimurium, a natural tool for activation of prodrug 6MePdR and their combination therapy in murine melanoma model. Applied microbiology and biotechnology. 2013, 97(10): 4393-4401.
10. J. X. Chen, B. Y. Yang, X. W. Cheng, Y. T. Qiao, B. Tang, G. Chen, J. Wei, X. F. Liu, W. Cheng, P. Du, X. F. Huang, W. H. Jiang, Q. G. Hu, Y. Q. Hu, J. H. Li*(通讯), Z. C. Hua*(通讯), Salmonella-mediated tumor-targeting TRAIL gene therapy displays better tumor suppression on melanoma mice model, Cancer Sci. 2012, 103(2):325-333.
联系方式：
Email: lijiah@cpu.edu.cn
