陈潇，博士，副教授，硕士生导师，2011年本科毕业于南京大学生命科学学院，2017年获得南京大学药学博士学位，2020年入职中国药科大学生物药物学院。主要研究方向为抗肿瘤和阿尔兹海默症药物作用机制研究和治疗靶点发现。任职以来，先后主持国家自然科学基金1项、省级自然科学基金2项、校级课题1项，参与国家及省部级课题多项。以第一或通讯作者在Signal Transduction and Targeted Therapy, British Journal of Pharmacology, Journal of Controlled Release, Theranostics等国际期刊发表多篇SCI论文。作为导师组成员，先后获得江苏省本科优秀毕业论文团队和中国药科大学校级本科优秀毕业论文团队。
联系方式：xchen@cpu.edu.cn
发表论文：
1. Chen X, Tian J, Zhao C, Wu Y, Li J, Ji Z, Lian D, Jia Z, Chen X, Zhou Z, Zhu B, Hua Z. Resveratrol, a novel inhibitor of fatty acid binding protein 5, inhibits cervical cancer metastasis by suppressing fatty acid transport into nucleus and downstream pathways. Br J Pharmacol. 2023 Dec 29.
2. Wang Y, Huo Y, Zhao C, Liu H, Shao Y, Zhu C, An L, Chen X*, Chen Z*. Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy. J Control Release. 2024 Feb 23;368:170-183.
3. Chen X, Wang Y, Ma N, Tian J, Shao Y, Zhu B, Wong YK, Liang Z, Zou C, Wang J. Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification. Signal Transduction and Targeted Therapy. 2020 May 21;5(1):1-3.
4. Song F, Li J, Shi Q, Wong YK, Liu D, Lin Q, Wang J, Chen X. Quantitative Chemical Proteomics Reveals Triptolide Selectively Inhibits HCT116 Human Colon Cancer Cell Viability and Migration Through Binding to Peroxiredoxin 1 and Annexin A1. Adv Biol (Weinh). 2023 Oct 4:e2300452.
5. Zhang X, Zhou J, Zhu Y, Wong YK, Liu D, Gao P, Lin Q, Zhang J*, Chen X*, Wang J*. Quantitative chemical proteomics reveals anti-cancer targets of Celastrol in HCT116 human colon cancer cells. Phytomedicine. 2022 Jul;101:154096.
6. Chen X, Li W, Xu C, Wang J, Zhu B, Huang Q, Chen D, Sheng J, Zou Y, Lee YM, Tan R. Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression. Theranostics. 2018;8(13):3504.
7. Wang Y, Huang J, Wang Z, Wang X, Liu H, Li X, Qiao H, Wang L, Chen J, Chen X*, Li J*. Extra virgin olive oil-based phospholipid complex/self-microemulsion enhances oral absorption of salvianolic acid B through inhibition of catechol-O-methyltransferase-mediated metabolism. Int J Pharm. 2022 Jan 5;611:121330.
8. Chen X, Wang Y, Tian J, Shao Y, Zhu B, Wang J, Hua Z. Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeletal Remodeling and Suppress EMT. Frontiers in pharmacology. 2021 Mar 26;12:368.
9. Chen X, Wang J, Fu Z, Zhu B, Wang J, Guan S, Hua Z. Curcumin activates DNA repair pathway in bone marrow to improve carboplatin-induced myelosuppression. Scientific reports. 2017 Dec 18;7(1):1-1.
10. Chen X, Wong YK, Wang J, Zhang J, Lee YM, Shen HM, Lin Q, Hua ZC. Target identification with quantitative activity based protein profiling (ABPP). Proteomics. 2017 Feb;17(3-4):1600212.
主持项目：
1. 云南云科特色植物提取实验室有限公司，平台建设专项（云南实验室建设），YKKF2023007，白藜芦醇抗黑色素瘤转移靶点鉴定和机制研究，2024-01至2026-12，40.0万元；
2. 国家自然科学基金委员会，青年科学基金项目，81903588，基于阿莫地喹为探针的AD中小胶质细胞TREM2表达调控机制研究，2020-01-01至2022-12-31，21万元；
3. 江苏省科学技术厅，基础研究计划（自然科学基金）—青年基金项目，BK20190799，以可改善AD认知障碍的阿莫地喹为分子探针探究调控小胶质细胞TREM2表达的新机制，2019-07至2022-06，20万元。
