高颖,特聘副研究员,硕士生导师,2017年本科毕业于华中农业大学食品科学技术学院,获得工学学士学位,2020年进入香港大学化学系学习并于2025年获得博士学位。于2025年聘为中国药科大学特聘副研究员。
研究方向:微生物次生代谢产物,宏基因组,宏转录组,生物信息学,深度学习算法,人体微生物,海洋微生物
生物合成基因簇的挖掘算法(基因组,宏基因组,代谢组等)及活性预测算法开发;
人体和海洋微生物来源的新颖次生代谢物挖掘;
高通量合成生物学和合成化学平台搭建;
其他方向:DNA编码分子库等大数据差异分析算法开发
发表文章
1.Gao, Y.#, Zhong, Z.#, Zhang, D., Zhang, J., & Li, Y. X. (2024). Exploring the roles of ribosomal peptides in prokaryote-phage interactions through deep learning-enabled metagenome mining. Microbiome, 12(1), 94. (IF = 11.528)
2. Song, Z. M., Cai, C., Gao, Y., Lin, X., Yang, Q., Zhang, D., ... & Li, Y. X. (2025). Deciphering the chemical landscape and potential ecological function of RiPPs from the untapped Archaea domain. Angewandte Chemie International Edition. e202501074. (IF =15.405)
3. Zhou, Y., Shen, W., Gao, Y., Peng, J., Li, Q., Wei, X., ... & Li, X. (2024). Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries. Nature Chemistry, 16(4), 543-555. (IF =18.211)
4. Cheng, Z., He, B. B., Lei, K., Gao, Y., Shi, Y., Zhong, Z., ... & Li, Y. X. (2024). Rule-based omics mining reveals antimicrobial macrocyclic peptides against drug-resistant clinical isolates. Nature Communications, 15(1), 4901. (IF =14.329)
5. He, B. B., Cheng, Z., Zhong, Z., Gao, Y., Liu, H., & Li, Y. X. (2022). Expanded Sequence Space of Radical S‐Adenosylmethionine‐Dependent Enzymes Involved in Post‐translational Macrocyclization. Angewandte Chemie International Edition, 61(48), e202212447. (IF =15.405)
联系方式:
Email:gaoyhlab@gmail.com